Expresión de búsqueda: SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE 
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Descriptor Inglés:   Silent Information Regulator Proteins, Saccharomyces cerevisiae 
Descriptor Español:   Proteínas Reguladoras de Información Silente de Saccharomyces cerevisiae 
Descriptor Portugués:   Proteínas Reguladoras de Informação Silenciosa de Saccharomyces cerevisiae 
Sinónimos Inglés:   Silent Information Regulator Proteins, S cerevisiae
Silent Mating Type Information Regulator Protein, S cerevisiae
SIR Proteins, S cerevisiae  
Categoría:   D12.776.354.750.750
D12.776.660.820
Definición Inglés:   A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS. 
Relacionados Inglés:   Sirtuins
 
Nota Histórica Inglés:   2003 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número del Registro:   37446 
Identificador Único:   D038281 

Ocurrencia en la BVS:
 

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